Docosahexaenoic acid–mediated, targeted and sustained brain delivery of curcumin microemulsion

Multifunctional MIL-S─CUR@FC nanoparticles: a targeted theranostic agent for magnetic resonance imaging and tumor targeted delivery of curcumin

Introduction: Noninvasive magnetic resonance imaging (MRI) and targeted drug delivery systems, usually referred to as theranostic agents, are being developed to enable detection, site-specific treatment, and long-term monitoring.   Materials and Methods: To elucidate the effects of coating on cellular uptake and biodistribution of n...

Brain Mini-Workshop: Blood Brain Barrier and Targeted Drug Delivery

Drugs are currently being developed for the treatment of serious brain disorders including glioblastoma, Parkinson’s disease, and Alzheimer’s disease. These include chemotherapeutic drugs and those based on neurotrophic factors such as glial cell-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and neurturin (NTN). Neurotrophic factors have therapeutic potential for...

Brain tumor-targeted drug delivery strategies

Despite the application of aggressive surgery, radiotherapy and chemotherapy in clinics, brain tumors are still a difficult health challenge due to their fast development and poor prognosis. Brain tumor-targeted drug delivery systems, which increase drug accumulation in the tumor region and reduce toxicity in normal brain and peripheral tissue, are a promising new approach to brain tumor treatm...

Nanoparticle-Based Brain Targeted Delivery Systems

Presenting a very dismal prognosis, glioblastomas present as one of the most malignant brain tumors [1]. In addition to its low prognosis, glioblastomas account for ~70% of all astrocytic and oligodendroglial tumors, making this one of the most common types of brain tumors [1]. Through the mutations of multiple pro-oncogenic genes, primary glioblastomas develop as other neoplasms but present as...

Advances in Targeted Drug Delivery